Blake MadrugaPostdoctoral Associate
He/Him

    Education

    • Ph.D. in Neuroscience, UCLA 2024
    • M.S. in Electrical and Computer Engineering, UCLA 2018
    • B.S. in Biology, UCLA 2015

    Short Biography

    I am interested in working at the interface of optical engineering and neuroscience, to design, build, and use novel optical tools to study neural circuits in new and impactful ways. While at UCLA, I designed and built an open-source, miniature multiphoton microscope system to resolve neural activity patterns in freely behaving mice. These miniature scopes enable new measurements and are designed to be very high performance, while being low-cost and accessible to users. In the Nedivi lab, I will be working to build a new benchtop two-photon microscope system to resolve fine neuronal structures, such as synaptic markers (both excitatory and inhibitory) across many spectral channels. The goal of the project is to not only resolve synaptic structural dynamics in vivo, but to also resolve calcium dynamics in the same neurons over faster time scales.

    While not in the lab, I enjoy working on mechanical and electronics projects (ask about my 1980’s inspired sci-fi robot) as well as cycling, bread baking, food and drink fermentation, coffee roasting, and hiking.

    Publications

    • Open-source, high performance miniature multiphoton microscopy systems for freely behaving animals
      Madruga BA, Dorian CC, Sehgal M, Silva AJ, Shtrahman M, Aharoni D, Golshani P.
      In Revision, Nature Communications, 2024-03.
    • Voltage imaging reveals that hippocampal interneurons tune memory-encoding pyramidal sequences
      Taxidis J, Madruga B, Melin MD, Lin MZ, Golshani P.
      In Revision, Nature Neuroscience, 2024-03.
    • A positively tuned voltage indicator for extended electrical recordings in the brain
      Evans SW, Shi DQ, Chavarha M, Plitt MH, Taxidis J, Madruga B, … , Lin MZ. (2023).
      Nat. Methods, 20(7), 1104-1113.